CAM201 Lecture Notes - Lecture 4: Systolic Geometry, Valvular Heart Disease, Heart Valve
Basics of the Cardiac Cycle
• Contraction and relaxation cause cyclic alterations in the pressures within the heart chambers.
• Pressure differences between heart chambers lead to the flow of blood between chambers
and also the major blood vessels in contact with the heart.
• The flow of blood through the heart is unidirectional because of the presence and properties
of the heart valves.
• There are 5 basic steps to a cardiac cycle
1. Diastole - Relaxation and Filling
Muscle:
• Atria relaxed
• Ventricles relaxed
Pressure:
• Ventricular pressure is less than atrial
pressure
• Ventricular pressure is much less than
pulmonary artery and aortic pressure
Valves
• AV valves open
• Semilunar valves closed
Blood flow:
• Blood flows passively into both atria and
ventricles down the pressure gradient
• High flow rate because of low resistance
2. Atrial Systole/Ventricular Diastole
Muscle:
• Atria contract
• Ventricles relaxed
Pressure:
• Ventricular pressure is less than atrial
pressure
• Ventricular pressure is much less than
pulmonary artery and aortic pressure
Valves
• AV valves open
• Semilunar valves closed
Blood flow:
• Active blood flow into ventricles as atria
contract
3. Ventricular Systole - Isovolumic Contraction
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Muscle:
• Atria relax
• Ventricles contracting
Pressure:
• Ventricular pressure is greater than atrial
pressure
• Ventricular pressure is rising but still lower
than pulmonary artery and aortic pressure
Valves
• AV valves snap shut
• Semilunar valves closed
Blood flow:
• Ventricular volume does not change, ie. No
blood flow (isovolumic)
4. Ventricular Systole - Ejection
Muscle:
• Atria relax
• Ventricles contracting
Pressure:
• Ventricular pressure is greater than atrial
pressure
• Ventricular pressure is greater than
pulmonary artery and aortic pressure
Valves
• AV valves snap shut
• Semilunar valves open
Blood flow:
• Blood ejected into pulmonary artery and
aorta from both left and right ventricles
• The volume of blood ejected = stroke
volume
• Atria begin to fill passively with blood
5. Ventricular Diastole
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Muscle:
• Atria relax
• Ventricles relaxing
Pressure:
• Ventricular pressure is greater than atrial
pressure
• Ventricular pressure has fallen below
pulmonary artery and aortic pressure
Valves
• AV valves closed
• Semilunar valves closed
Blood flow:
• Ventricular volume does not change, ie. No
blood flow (isovolumic)
Then the cycle restarts
Wiggers Diagram
• The diagram illustrates the coordinated variation in each factor/values as the heart beats
• The Wiggers diagram contains:
o Details of pressure changes in the LEFT side of the heart
o Details of volume changes in the LEFT side of the heart
o An ECG
o Phonocardiogram (heart sounds)
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Document Summary
Blood flow: blood flows passively into both atria and ventricles down the pressure gradient, high flow rate because of low resistance, atrial systole/ventricular diastole. Pressure: ventricular pressure is less than atrial pressure, ventricular pressure is much less than pulmonary artery and aortic pressure. Blood flow: active blood flow into ventricles as atria contract, ventricular systole - isovolumic contraction. Pressure: ventricular pressure is greater than atrial pressure, ventricular pressure is rising but still lower than pulmonary artery and aortic pressure. Blood flow: ventricular volume does not change, ie. no blood flow (isovolumic, ventricular systole - ejection. Pressure: ventricular pressure is greater than atrial pressure, ventricular pressure is greater than pulmonary artery and aortic pressure. Blood flow: blood ejected into pulmonary artery and aorta from both left and right ventricles, the volume of blood ejected = stroke volume, atria begin to fill passively with blood, ventricular diastole.