CAM201 Lecture Notes - Lecture 1: Aorta, Sinoatrial Node, Intercalated Disc

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8 Jun 2018
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Learning Objectives
Describe the general structure, makeup and function of the cardiovascular system,
including the pathway of blood flow through the heart and circulation
Revisit the concepts of resting membrane potential and action potentials and apply these
concepts to cardiac muscle cells
Describe the process of excitation-contraction coupling cardiac muscle
Describe how the specialized wiring of the heart relates to and enables normal heart
function
Understand and explain how the autonomic nervous system can modify heart rate,
contractility and conductivity within the heart.
Circulatory System Functions
Transport
o Oxygen
o Nutrients
o Waste Products
o Hormones
o Immune cells
Distribution of heat
Major Organs
Heart
Blood Vessels
Basic Structure of the Circulatory System
Composed of 4 Parts:
The pump (heart)
The plumbing (arteries, capillaries and veins)
The wiring (control and coordinate pump)
Appropriate medium/fluid (blood)
The Heart is a Dual-pump Setup
Right Side
Right Atrium
o Weak pump
o Receives blood from periphery via vena cava
o Primes right ventricle
Right Ventricle
o Stronger pump
o Pumps blood out of heart and through pulmonary circulation
Left Side
Left Atrium
o Weak pump
o Receives blood from pulmonary circulation
o Primes left ventricle
Left Ventricle
o Strongest pump
o Pumps blood through the aorta to the peripheral circulation at very high pressure
Heart valves allow for unidirectional movement of blood through heart
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Each Chamber has Two Basic States During a Cardiac Cycle
Diastole (Relaxation and Filling )
Arteriovenous (AV) valves are open
Semilunar valves are closed
Atria and ventricles are both relaxed
Atria and ventricles are both passively filling with blood
1.5. Atrial Systole/Ventricular Diastole
Atrioventricular (AV) valves are open
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Semilunar valves are closed
Atria contract and empty last bit of blood into ventricles
Both ventricles still relaxed
Systole (Contraction and Ejection)
Atrioventricular (AV) valves are closed
Semilunar valves are open
Atria relax
Both ventricles contract and eject blood out of heart
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Document Summary

Circulatory system functions: transport, oxygen, nutrients, waste products, hormones. Composed of 4 parts: the pump (heart, the plumbing (arteries, capillaries and veins, the wiring (control and coordinate pump, appropriate medium/fluid (blood) Right side: right atrium, weak pump, receives blood from periphery via vena cava, primes right ventricle, right ventricle, stronger pump, pumps blood out of heart and through pulmonary circulation. Left atrium: weak pump, receives blood from pulmonary circulation, primes left ventricle. Left ventricle: strongest pump, pumps blood through the aorta to the peripheral circulation at very high pressure. Heart valves allow for unidirectional movement of blood through heart. Each chamber has two basic states during a cardiac cycle: diastole (relaxation and filling , arteriovenous (av) valves are open, atria and ventricles are both relaxed, atria and ventricles are both passively filling with blood. Atrial systole/ventricular diastole: atrioventricular (av) valves are open.

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