CAM201 Lecture Notes - Lecture 1: Aorta, Sinoatrial Node, Intercalated Disc
Learning Objectives
• Describe the general structure, makeup and function of the cardiovascular system,
including the pathway of blood flow through the heart and circulation
• Revisit the concepts of resting membrane potential and action potentials and apply these
concepts to cardiac muscle cells
• Describe the process of excitation-contraction coupling cardiac muscle
• Describe how the specialized wiring of the heart relates to and enables normal heart
function
• Understand and explain how the autonomic nervous system can modify heart rate,
contractility and conductivity within the heart.
Circulatory System Functions
• Transport
o Oxygen
o Nutrients
o Waste Products
o Hormones
o Immune cells
• Distribution of heat
Major Organs
• Heart
• Blood Vessels
Basic Structure of the Circulatory System
Composed of 4 Parts:
• The pump (heart)
• The plumbing (arteries, capillaries and veins)
• The wiring (control and coordinate pump)
• Appropriate medium/fluid (blood)
The Heart is a Dual-pump Setup
Right Side
• Right Atrium
o Weak pump
o Receives blood from periphery via vena cava
o Primes right ventricle
• Right Ventricle
o Stronger pump
o Pumps blood out of heart and through pulmonary circulation
Left Side
• Left Atrium
o Weak pump
o Receives blood from pulmonary circulation
o Primes left ventricle
• Left Ventricle
o Strongest pump
o Pumps blood through the aorta to the peripheral circulation at very high pressure
Heart valves allow for unidirectional movement of blood through heart
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Each Chamber has Two Basic States During a Cardiac Cycle
• Diastole (Relaxation and Filling )
• Arteriovenous (AV) valves are open
• Semilunar valves are closed
• Atria and ventricles are both relaxed
• Atria and ventricles are both passively filling with blood
1.5. Atrial Systole/Ventricular Diastole
• Atrioventricular (AV) valves are open
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• Semilunar valves are closed
• Atria contract and empty last bit of blood into ventricles
• Both ventricles still relaxed
• Systole (Contraction and Ejection)
• Atrioventricular (AV) valves are closed
• Semilunar valves are open
• Atria relax
• Both ventricles contract and eject blood out of heart
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Circulatory system functions: transport, oxygen, nutrients, waste products, hormones. Composed of 4 parts: the pump (heart, the plumbing (arteries, capillaries and veins, the wiring (control and coordinate pump, appropriate medium/fluid (blood) Right side: right atrium, weak pump, receives blood from periphery via vena cava, primes right ventricle, right ventricle, stronger pump, pumps blood out of heart and through pulmonary circulation. Left atrium: weak pump, receives blood from pulmonary circulation, primes left ventricle. Left ventricle: strongest pump, pumps blood through the aorta to the peripheral circulation at very high pressure. Heart valves allow for unidirectional movement of blood through heart. Each chamber has two basic states during a cardiac cycle: diastole (relaxation and filling , arteriovenous (av) valves are open, atria and ventricles are both relaxed, atria and ventricles are both passively filling with blood. Atrial systole/ventricular diastole: atrioventricular (av) valves are open.