300889 Lecture Notes - Lecture 3: Tunica Intima, Endothelial Dysfunction, Phagocytosis

• School: UWS
• Department: University of Western Sydney
• Course: 300889
• Professor: unknown

Document Summary

Cardiovascular diseases processes in the development of hypertension, atheroma, thrombi, shock, and pathological consequences. Wbcs move to tunica intima > lipids (ldl) move to tunica intima . So in summary: chronic endothelial injury > hypertension, smoking, toxins, viruses, endothelial dysfunction > increased permeability, leukocyte adhesion, monocyte adhesion and emigration, smooth muscle emigration from media to intima. Macrophage activation: macrophages and smooth muscle cells engulf lipid, smooth muscle proliferation, collagen and other ecm deposition, extracellular lipid. Essential meaning that it"s primary, that there isn"t something else making it go up. There are 2 types of bone: compact (dense, spongy (cancellous) The functions of bone extend beyond simply providing movement or protection. It"s also important in storing and releasing ions such as calcium and phosphorus. spongy bone is located in the ends of long bones, and enclosed between outer layers of compact bone in most other bones. Lacuna is a small space containing osteocyte in bone.