ANHB1102 Lecture Notes - Lecture 27: Zygosity, Directional Selection, Balancing Selection

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Reconstructing Evolutionary History Using Genetic Variation (Video #1)
Fossils: limitation:
- Typically only few fossils available at a
particular time for particular species
- difficult to assess variation that exist
within population
Useful if can use contemporary species and its
information to reflect time and construct
history:
- Do this by utilizing genetic variation.
After separation, population and species
accumulate genetic differences. Overtime,
results in speciation.
- If initially start with single species, its
variation broken into 2 population= can
cause 2 different species of population
that are isolated.
Cladogenesis:
- evolutionary splitting event
- Evolutionary mechanism/process due to
adaptive evolution that leads to
development of greater number of sister
organisms.
- This process reflected using
phylogenetic genetic trees.
- Each branch forms a clade which reflect
accumulation of genetic changes.
- Closer you are within the tree genetically more related.
- Genetic variation is indicator of human
evolution and reconstruction of history.
- Lesser the genetic distance, common ancestor is
recent!
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Molecular clock:
- Evolutionary time and genetic
differences proportional
- As divergence time varies, theres a
linear relationship between divergence
time as estimated by fossil record and the
inferred nucleotide substitutions between
the same species
- Can use this to estimate other
divergence time based nucleotide
differences
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Early Human Evolution (Video #2)
- Utilize genetic information and contemporary human
population to examine early human evolution
- Genetic information can be utilized in form of
phylogenic trees or examine genetic distance to look at
relationship between humans and primates (early evolution,
how we evolved, and human ancestry)
- Can use molecular clock to examine divergence time
and accumulation of genetic variation is proportional to time
Examine different models of early
human evolution:
(Green arrows = current)
1) African replacement = replace
with minimal or no mixing with
population (no hybridization)
2) Early humans evolve from Africa
and migrated to other areas but
some interaction/mixing with local
population
3) Multiregional model = modern humans evolve concurrently in Europe Africa and Asia but there
was sufficient gene flow between populations to maintain continuity of single species
Examine current population to see which model is more
likely to occur.
To differentiate 2 main models (African replacement and
multiregional):
- Mito DNA Is has 15-20 fold of mutation rate than
nuclear genome so it allows us to look at evolution in time
scale of few thousand years instead of millions
- The deepest branches that deep into center of circle
are from African population
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Document Summary

Reconstructing evolutionary history using genetic variation (video #1) Fossils: limitation: particular time for particular species within population. Useful if can use contemporary species and its information to reflect time and construct history: After separation, population and species accumulate genetic differences. Overtime, results in speciation. difficult to assess variation that exist. If initially start with single species, its variation broken into 2 population= can cause 2 different species of population that are isolated. Evolutionary mechanism/process due to adaptive evolution that leads to development of greater number of sister organisms. This process reflected using phylogenetic genetic trees. Each branch forms a clade which reflect accumulation of genetic changes. Closer you are within the tree genetically more related. evolution and reconstruction of history. Lesser the genetic distance, common ancestor is recent! As divergence time varies, there"s a linear relationship between divergence time as estimated by fossil record and the inferred nucleotide substitutions between the same species.

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