IMED2004 Lecture Notes - Lecture 3: Limb Development, Blastula, Pattern Formation
26 Mar 2020
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Document Summary
In multicellular organisms, life begins as a single cell: with few exceptions, somatic cells contain same genetic information as zygote (fertilized egg). Is it a useful model: drosophila does have different embryonic development compared to vertebrates, but, many developmental genes which are conserved in vertebrates (e. g. hox genes) identi ed in. Development & homology: pax (paired box) genes encode transcription factors (tf) important in early development & tissue specification, as family- influence different cell differentiation, can conclude that they have a conserved function, e. g. Pax6/eyeless orthologous gene required for eye development across many species. Cells can be influenced by their environment: 1st panel- 2 regions at opposite ends- a is dorsal and become determined- will become something and differentiate into the right axis, b- transplant into a. If early enough and before a has been determined. And will become a cell: but if after determined- then b cell will become into b tissue but in location of region a.
