IMED3002 Lecture Notes - Lecture 7: Noxious Stimulus, Neuropathic Pain, Visceral Pain
28 May 2020
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Sensitization: enhanced sensation to noxious stimuli following injury. Stimulus provided by noxious mechanical, thermal or chemical input. Caused by lesion or trauma to nerve or cns. Substance p neurotransmitter it"s a protein, hence long time to produce, and will stay bound to receptors for minutes. Classes of pain sensation: do not give us perception of cold, head or etc, just activated by this stuff, and will only feel pain. Various classes of pain pricking, stabbing, pinching (mechanical) burning, freezing (thermal ) aching, stinging, soreness (chemical ) visceral (mechanical, chemical) Protective function: warn of injury that should be avoided or treated. Trains the brain to not do the thing again (affects the brain) Fast pain: sharp and well localized (is much slower than sensory and motor movement we have) transmitted by myelinated axons (a- fibres)- fast. Slow pain: dull aching sensation, not well localized, transmitted by unmyelinated axons (c fibres)- m/s: a- fibres (thinly myelinated, glutamatergic.
