PHAR2210 Lecture 2: PHAR2210 Notes Module 1
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Plants'as'Drugs:'
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Historical'Origins'of'Pharmacology:'
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Famous'Medicinal'Plants:'
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Natural'Sources'of'Drugs:'
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Problems'Slowing'the'Emergence'of'Pharmacology:'
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Modern'Pharmacology:'
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Drug'Definition:'
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Naming'Drugs:'
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Common'Stems'in'Drug'Names:'
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Document Summary
Johann christian reil (1759 1813) o german physician and scientist who made celebrated contributions to the fields of pharmacology and psychiatry o 1797 paper an article on the principles for a future pharmacology o proposed 8 rules still relevant to pharmacology. Willow tree (salicylates) o ~200ad doctors used willow leaves as analgesics (painkillers) o 1763 rev e stone reported antipyretic effects of willow bark to royal society (uk) (fever relieving) o 1828 buchner, isolated pure salicin from bark o 1897 bayer, industrial synthesis of aspirin (acetylated salicylic acid) Belladonna (atropine) o medical uses in ancient india o causes rosy cheeks + pupil dilatation o 1831 active constituent atropine isolated o 1867 atropine shown to block cardiac vagal stimulation o used in ophthalmology & medicine. Reluctance to apply scientific principles o poor understanding of human physiology, chemistry, biochemistry, genetics etc o little appreciation of need for well controlled, bias free clinical investigation of drugs.
