PHAR2210 Lecture Notes - Lecture 4: Renal Function, Afferent Arterioles, Feces
Document Summary
Adme iii: drug excretion: the permanent removal of drugs from the body via body fluids and secretions, expired air or tissue shedding, key determinant of the pharmacology & toxicology of drugs. In general, hydrophilic drugs undergo minimal metabolism in the liver: excreted unchanged in urine. Lipophilic drugs are converted to hydrophilic metabolites that are then removed by kidneys and excreted in urine. Influence renal drug: urine (kidneys) (most common, faeces (bile, expired air (lungs, milk, hair, skin/sweat. Glomerular filtration: free (unbound) drugs in filtered in pores blood through glomerulus are, pass into ultrafiltration, protein-bound drugs remain in the blood, 2. Passive reabsorption: some drugs can passively diffuse back into blood, occurs for small, lipophilic & non-ionised drugs, 3. Active transport: energy-dependent transporters move drugs from blood into urine, mostly occurs at the proximal tubules. Filtration: glomerulus is a spherical capillary cluster encased within a cup-like container called. Bowman"s capsule: blood filtered through glomerular pores (aided.
