NEUR 3204 Lecture 4: Lecture 4- serotonin
16 Jul 2020
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It is the rate limited enzyme, not the rate limiting step: 1) enzye tryptophn hydroxylase (tph) convert tryptophan ti 5-hydrocytryptophan (5- Increase opening of k+ channels and membrane hyperpolarization: similar activity to d2 and alpha 2 receptors, similar activity to d2 and a2 receptors; Leads to decrease cell firing in post-synaptic cell (post-synaptic receptor) or serotonergic neuron itself (auto-receptor). Large role in cogntion and mood: primarily responsible for activating phosphoinositide 2nd messenger system. Lack of sun and vitamin d: sad is thought to be caused by a reduction in sunlight, and may be related to reductions in serotonin (although, nothing has been proven yet). Typical ssri"s are able to reverse depressive-like symptoms of sad. Interestingly, one of the symptoms of sad is overeating and cravings for carbohydrates and sweet foods, which usually results in weight gain: other symptoms are: sleeping disturbances, lethargy, hopelessness, etc, can diet affect your mood, yes.
