PHYS-3306EL Lecture Notes - Lecture 3: Alpha Particle, Carcinogen, P53

• School: Laurentian
• Department: Physics
• Course: PHYS-3306EL
• Professor: K.Leszczynski, D.Boreham

Document Summary

Uv light (cid:1) rare (cid:1) (cid:1) the individual will develop tumours wherever uv light contacts his/her body: cataracts will develop in the eyes. If a virus destroys the p53 protein, then the cell won"t self-destruct. (cid:1: example, human papillomavirus (hpv) (cid:1) causes cervical cancer, a sexually transmitted cancer (stc) (cid:1) hpv makes the e6 oncoprotein, which inactivates p53. In the area receiving radiation during radiotherapy: examples (cid:1) uv damage involves 2 pyrimidines, cyclobutane dimers/6-4 photoproducts (cid:1) difunctional alkylating agents, such as cisplatin, powerful hemotherapeutic drug (cid:1) especially for ovarian cancer. It"s thought that about 10% of people are radiosensitive and that about 10% of people are radioresistant: 2 gy is the normal dose for radiotherapy because it"s ideal for most people. If not fed, will die (cid:1) food (cid:1) split. 100x: surviving fraction (sf) (cid:1) percentage of cells seeded that grow into colonies (cid:1) with consideration of plating efficiency (cid:1)