CMMB 403 Lecture Notes - Lecture 20: Beta-Catenin, Wnt Signaling Pathway, Maternal Effect
1 Jan 2019
School
Course
Professor
Document Summary
The rest of amphibian development part 2. The signals that induce the formation of the organizer in a specific location. The organizer forms where two signals converge. Nuclear beta-catenin is stabilized in dorsal cells of the blastula in cells below where the organizer will form and at the site of the future organizer itself. A cocktail of dorsal mesoderm-inducing signals (mostly nodal-related tgf-beta family members) is secreted by cells of the nieuwkoop centre (which is just below where the organizer forms) Nieuwkoop centre is in the vegetal pole. Organizer forms opposite to sperm entry location. Before sperm entry, there is polarity in the oocyte. Polarity before fertilization is generated by maternal mrnas. The vegetal cells, which will form the endoderm, induce the cells above them to form mesoderm. Necessary to induce mesoderm above cells of the endoderm. Translate this mrna after fertilization, proteins made will induce mesoderm formation.
