CMMB 461 Lecture Notes - Lecture 15: Drug Allergy, Wild Type, Estrogen Receptor
18 Nov 2018
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Heterozygotes that are sensitive to a particular drug may contain the orf that encodes the drug target. Drug target is usually a protein, that it binds to. If you knock out both copies of an essential gene, phenotype is death. Heterozygous is viable because wt copy can still make functional protein. Gene produces a protein that the drug inhibits. Drug inhibits, wt allele dose drops to less than one. When dosage drops below 1, see cell death because of reduced fitness this is called. Drug treatment triggers activation of buffering pathways to deal with drug effects. If you expose this cell to the drug, it will cause toxic effects in the cell. Cell activates a pathway the buffers the toxicity of the drug. Drug damages dna, cell activates dna repair pathways or, Drug works on proteins causing them to denature, except wt cell to activate pathways that activate chaperones that try to refold dna.
