CMMB 461 Lecture Notes - Lecture 28: Wnt Signaling Pathway, Dishevelled, Power Law
29 Dec 2018
School
Course
Professor
Document Summary
Probability that a protein interacts is a power law (as observed in other interactomes) Number of interactions for a protein is related to its essentiality. 93% of proteins have <6 links (21% essential), while 0. 7% of proteins have >15 links are 62% essential. To get this information, they ran a large scale 2 hybrid. Saw, when plotted, you see a power law meaning that there are many proteins with few interactions and a few proteins with many interactions. You can find the power law in many different networks. 401 human proteins including a subset associated with diseases and 911 interactions. Wnt signalling is a stem cell growth factor and major oncogenic pathway. No dishevelled (phosphoprotein of frizzled receptor in wnt pathway), see no induction. See that induction is less than if you just added dishevelled alone, so protein is likely to be a repressor. If proteins do interact, they must have some sort of effect.
