BIOL 1080 Lecture Notes - Lecture 2: Drosophila Melanogaster, Evidence-Based Medicine, Fluorescent Tag
18 Nov 2017
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Document Summary
Experimental models: simulations with mathematic models/computer (in silico, in vitro (in glass) and ex-vivo (out of the living) models (cell culture, isolated tissues/organs, animal models, human subjects. Transparent- facilitates the study of cell differentiation ex. embryonic metabolism- turning on and off genes and pathways ex. use a fluorescent tag to follow digestion of a nutrient, synthesis of proteins, cholesterol ect. Life cycle and development are very sensitive to environmental conditions ex. used in neuropharmacology research to study effects of drugs and alcohol. Often used to study lifestyle effects on metabolism (diets, exercise, drugs) Tend to take a more severe approach than with humans ex. 50% fat diets, 10 hours intense exercise per week ect. Not a very good model for human infants (nutrition, metabolism) Some genetically modified rats, but not as common as with mice ex. Zucker rats lack leptin receptors and are obese, still make leptin. Zucker rats are used to study obesity and diabetes.
