BIOL 1090 Lecture Notes - Lecture 18: Cell Damage, Cell Membrane, Apoptosis
Document Summary
Glycolysis produces pyruvate and if there is no oxygen goes into fermentation and produced lactate. Mitochondria plays a important role in programming cell death (apoptosis) Blebbing of plasma membrane membrane pieces, falls apart. Phagocytosis is when the pieces of the dead cell is broken down and reused. Intrinsic pathway: signals mitochondria to go through apoptosis, proapoptoic proteins simulate mitochondria to leak proteins. Cell damage signals proapoptoic to activate and create a apoptosome complex and make executioner procaspases that turn into executioner caspase which then go through apoptosis. Release of cytochrome c and nuclear fragmentation during apoptosis. Caspases: disrupts cell adhesion, destroys lamins, breaks down cytoskeleton, dnase are activated. Cytoplasma everything in the cell other then nuclease including organelles. Cytosol is the stuff in between the organelles.
