KIN217 Lecture Notes - Lecture 13: Glycogen, Ciprofloxacin
28 Apr 2018
School
Department
Course
Professor
Lech.lre, 13
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Chop+er 2g - Gtyccgen Degr-adctrofl
'Glycogen a hgrrtv bronched hornopotymer of luccse gresent in al\ +tssu€s
' Lnrges+ s*ores or€ \n XL d
9 Lrver rmrn{qlns l"\ood g\ucose d f,rstrrrS
. 'Nff dePe-ndent o{ Oz (g\Yco\Ys'9)
' Largest ?6ot of gryco$en 19 s(€.\e*ca\ rnusc\e
L--+ fnore conc.€.n+rotgd in \ivef b,Jr cnuch fnore gKe\e\c"\ fr\$:(\e nnugs
.g\YrcEen Qronu\€s are tormed d stored rn 4he cytop\cr!(v\
GIll;gcn lwuciud€
'sfv6igl$ ehotn
l-rr( t,"t g\yc_cs€rrc bcrrc\S
.brancheS Le.very \O*t fesidue)
\+Ld t.L c1\ycr,\'C\rc lo-n,O
. I glyoogerrifl at cor€
.+ehzJm€ invotved 'n rnrhoLtng sSn{hesis
- Non'reducinS ends ({:ree -oH 3rocris\ o{chaoS 66 qrK{er\oC
G\vtcri<n Brn:ctKctct.n
.3\vc€en --) g\ucoSe 6 - ghcsphot€
't{ enzgrn€S lnvo\ved
+ I to deSrade gtycoSen
. re,leo6€ $uccse I -PhosQhage
u> Z+o re.rnoie\ g\ycogen (on ab'{onctrono\ e62516s 16 g*Kargo|t'gs)
'fnove su.re $Ycogen femo\ns o s'"bstrqte
€ t +o conv€r{ breokdodn Proc\uct to usc{o\e' produc€
. gtrrcssg I -ghosghote $' $ucose 6-Shosghat€
( I e trv, ,r5 (r\.1c u$c n
. 5lycoEc-n phcspho ry\oSe
+. &grades gtycogen from +he rror.rfecitrtn$ erctS
9cetotyzes a ghes,ghor6rl\rS r€c;cti<j,-\ +hat yre\ds 5\ucose. i.-g\ugho€<-
'feacttsn bY€aES o. At-q 3\qcoSrdlc bond us\nq
.ghosghote 3ets attachect to C-[ of gtucose +4\
. $\ucose I -phosphote
H phoslhote o\reody on g\ucoS9
a\so rerrnrns +ro.pped rn cel\
t--+ No AT P r-r-(I-ir<<\
llg 111 gci\+= \rrrs; Crlyco$ r,r
.Pco\ore.yn: g\Vctrqen phcsphoryl6s€ can nol c\eove
a \eaves t{ gtuccse resrd,u€s
D con on\5 c,\eave otr-\ gryccrsrdic bondS
it'n _-\\'
3\ucose + q\yroorerr
rlpncF,pf'ate J ' -J
neo.r bronch iotnts
