PHRM 111 Lecture Notes - Lecture 6: Stratum Corneum, Coal Tar, Dithranol
Document Summary
Emollients, keratolytics, corticosteroids, vit d derivatives (calcipotriol), tazarotene, coal tar, anthralin. *nails, palms and soles do not respond well to treatment (thicker skin) Moderate-severe : phototherapy (used in conjunction with other treatment) Moa: alleviate dryness ( hydrate stratum corneum, may reduce pruritus) Salicylism (extensive application and systemic absorption): nausea/vomiting, tinnitus, hyperventilation. Used in combination with corticosteroids, anthralin, uvb light or oral therapy. Do not apply in circular motion (folliculitis) Low potency (hc 1%) face, groin, skin folds. Moderate potency (betamethasone 0. 1%) scalp, elbows, knees. High potency (amcinonide 0. 1%) resistant, thick plaques. Regimen: use bid until skin is normalized (3-4 weeks) then reduce potency and use on weekends only for maintenance. Steroids + occlusion (saran wrap at night caution with atrophy) Local hair growth , telangiectasia ( ), purpura (easy bruising), striae, epidermal and dermal atrophy. Vitamin d3 analogue affects calcium and bone metabolism. Irritant (careful on face), hypercalcemia risk (max 100g/week) Better tolerated than calcipotriol no irritation or photosensitization.
