PHRM 211 Lecture Notes - Lecture 25: Pulmonary Hypertension, Pulmonary Artery, Cardiac Catheterization
Document Summary
Can be progressive with a poor prognosis if not treated. Pharmacology treatment options have increased significantly over the past 10 years. Results in reductions in patient symptoms, disease progression and mortality, improved exercise capacity. Pulmonary hypertension : a hemodynamic and pathophysiological condition defined as an increase in mpap confirmed by right heart catheterization. 14 3 with upper limit of 20. Changes in co and pleural/alveolar pressure affect pulmonary blood flow. Only organ to receive entire cardiac output (co) Different reactions compared to the systemic circulation. Normally in a state of mild vasodilation. Mean pulmonary arterial pressure (in ph): > 25 mmhg. Without treatment, right heart dysfunction = progressive symptoms & death. Group 2: ph owing to left heart disease ( copd, interstitial lung disease ) Group 3: ph owing to lung diseases and/or hypoxia. Group 5: ph with unclear multifactorial mechanisms ( sarcoidosis ) Note : pah ph (not all ph is pah)
