BIO202H5 Lecture Notes - Lecture 34: Negative Feedback, Positive Feedback, Chemical Synapse

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1 Oct 2018
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Step 1: first segment of axon (a) is depolarized to +30 mv. Step 2: depolarization causes spreading of the local current that depolarizes the next axon segment (b) to threshold. Step 3: when depolarization of the next segment (b) reaches threshold, action potential is generated and when +30 mv is reached, the na+ channels close. Step 4: step 2 is repeated at the next segment of the axon (c) An action potential is comprising of both positive and negative feedback loop systems. Step 1: at -70 mv, the activation gate of voltage- gated na+ is closed. Step 2: a suprathreshold graded potential opens the activation gate and na+ can enter the cell. Positive loop system that ensure rapid depolarization. Step 4: as membrane is closer to +30 mv, the activation gate closes and na+ cannot enter the cell. Positive feedback: depolarization of the membrane and sodium entry into the cells.

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