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ENV100Y5 Lecture 2: Lec 2

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magentakoala127
15 Sep 2017
School
UTM
Department
Environment
Course
ENV100Y5
Professor
Barbara Murck

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Related Questions

Show transcribed image text

make a table for the DNA repair pathways

Repair pathway

DNA lesion(s) fixed

cause(s)of DNA lesion(s)

DNA lesion recognized by

Steps (incl. enzymes) of repair

cell cycle stage the pathway is activein

Notes

Nucleotide excision repair (NER)

transcription coupled-NER:

Xeroderma pigmentosum and Cockayne syndrome are caused bymutations in NER-related genes

global genomic-NER:

Base excision repair (BER)

Mismatch repair (MMR)

Non-homologous end joining

Homologous recombination

What are MMR, BER, and NER? How do they differ in the types of mutations they can repair? What are the nucleases involved in these repair mechanisms? Give the specific properties and functions of one nuclease for each of these repair mechanisms.