PSY397H5 Lecture Notes - Lecture 8: Low Frequency, Amygdala, Cerebellum
Document Summary
But for both sides to go through changes, there has to be some backward signals. Integrins: provide a bridge between pre and post; it can signal both ways: dm: highly diffusible gases, can send retrograde signals, can alter the function of neighboring synapses. Silent synapses: synaptic connections that has receptors missing: ampa: amplifier of calcium, if it is not positioned, synapse will not go through, so no action potential. Prozake: memory lose; small molecules that alter memory. Company called cortex: when glutamate binds to ampa receptor, it opens more, leading to more calcium flowing. This leads to better connections and better memory. Trials for animals: they will learn and remember better. But the mice were dying after the dosage because of calcium toxicity: neurons become too active and die. Depotentiation: when you induce ltp, then s831 (amino acid) can get phosphorylated. Modulation: norepinephrine: b-adrenergic: enhance the output signal, strengthening of ltp: bdnf.
