PSY397H5 Lecture Notes - Lecture 7: Chemical Synapse, Synaptic Plasticity, Vesicle Fusion
Document Summary
If a lot of sodium it gets depolarized easily. If a lot potassium it gets hyperpolarized easily: changes in number of total synaptic connections between two cells, changes in the structure of pre and/or post-synaptic terminals, how they actually look like. Ultimately, changes in the size of epsp will translate to changes in the probability of action potential generation. Action potentials may be triggered due to temporal integration in ltp induction: low frequency stimulation doesn"t change much, but high frequency stimulation over time can change the synapse to make it more responsive. Action potentials may be triggered due to gaba-ergic interneuron inhibition. If you inhibit inhibition it is the same thing as increasing excitation. It just makes it less likely to fire. If you block gabaergic neurons then it reduces the probability for action potentials to transfer to the post synaptic neuron.
