BIOL 430 Lecture Notes - Lecture 12: Resting Potential, Adenylyl Cyclase, Cyclic Guanosine Monophosphate
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Signal transduction: ligand is coupled to a neurotransmitter receptor via a g protein; it responds to intracellular signals induced by binding of neurotransmitter to a separate receptor protein. E. g. signals activating different channels include ca2+, cyclic gmp, and the ga subunits of trimeric g proteins. Ligand binds g protein alpha subunits bind cellular membrane enzymes ( i. e. adenylate cyclase, phospholipase c) intracellular response. Camp via g protein opens another ion channel or stimulates cell secretion. Glucose low in blood - pancreas releases glucagon; liver to take glycogen. Onto neuronal signaling specifically recall the action potential and convert to glucose electrical disturbance or input signal. ** a variety of signals (temperature, light, sound, smell, pressure) can produce an. ** if the signal triggers a large enough change in conductance for an ion, then the. ** brief, but large regenerative wave of depolarization (movement of ions generating electric current) and repolarization of the axonal cell membrane
