BIOL 430 Lecture Notes - Lecture 16: Catecholamine, Metabotropic Receptor, Axon Terminal
Document Summary
Sometimes can package more than one neurotransmitters (co-secretion) Do not memorize what is in each (just be aware they are different) Bind to g-protein coupled receptors on post synaptic neuron. Synthesized in the rough er and golgi. They are not rapidly degraded or taken up, so the amount of time for their activity is not limited as in neurotransmitters. They can either dampen or enhance the excitability of their effector neurons. Ex. substance p, oxytocin, vasopressin, neurotensin, met/leu enkephalin. Synthesized in cytosol of presynaptic neuron terminals. Re-released by the presynaptic neuron and either excite or inhibit the post synaptic neuron. They are quickly degraded in the synaptic cleft or taken up by the presynaptic neuron to limit the amount of time they are in the synaptic cleft. imported w/ in axon terminal/// c be pulled back and re-used. More ionotropic > bind and open up ion channel. Inhibitory nts open k+ or cl- channels hyperpolarization.
