NUSCTX 10 Lecture Notes - Lecture 13: Energy Economics, Peptide Hormone, Leptin
16 Dec 2015
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Document Summary
Often stated: obesity is state of energy imbalance (intake>expenditure) Consider energy intake vs weight gain over a year. Is homeostasis active or passive (set point or settling point) Energy expenditure- adaptive response to increased or decreased energy intake. Peptide hormone produced by adipocytes that signals information about the amount of body fat. If you"re strong, (muscles) lean tissue burns more calories. Bariatric surgery: surgical, morbidly obese, band around intestines, restrict food intake of stomach, types of bariatric surgery. Possible effects of exercise on the energy balance system. Calorie restriction, reducing caloric intake without malnutrition. Growth stops, reproductive system, thyroid axis (utlity and downside in obesity), insulin sensitivity, (therapeutic application) weight lost behavioral changes. Metabolic response to fasting (glycogen depletion, fatty acid oxidation, brain keto-adaptation: run out of glycogen, nitrogen losses, baseline fuel mixture, burning fat, ketosis; reduced n-losses, brain stops uses glucose and uses fat (keto-adaptation; greatly reduced n-losses; further adaptations.
