CAS CH 203 Lecture Notes - Lecture 10: Ester, Post-Translational Modification, Signal Transduction
Document Summary
Phosphoryl transfer and the kinetics and thermodynamics of energy currency in the cell: atp and gtp. Mechanism of phosphoryl transfer with atp: use of atp in vivo. Atp as the energy currency of the cell: roles of phosphorylated species in biology. P is an element that many of you have not previously thought about, but it is a constituent of almost all the cofactors in the cell (nad, Fad, coa, tpp, vitamin b1 etc), of the energy currency of the cell (atp and gtp), and of the molecules involved in information transfer in the cell (dna, rna). In addition, in both the glycolysis and gluconeogenesis pathways, all the sugars are phosphate monoesters. Phosphorylation is also a major regulatory mechanism in signal transduction pathways (fight or flight; fed state or starved state). S, t, y are commonly phosphorylated in mammalian systems in a post-translational modification process.
