CAS PS 333 Lecture Notes - Lecture 2: Gaba Receptor Antagonist, Opioid Overdose, Zolpidem
15 Feb 2018
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Most common drug on campus: vicodin (prescription analgesic) Most companies are looking for a prescription analgesic with the same therapeutic effects as. Vicodin but with a higher ti (therapeutic index) Drug vehicle physiological saline, or 3% everclear; solution used to dissolve the drug to inject it. Prob not would target something else: ambien if you give ambien after a gaba antagonist there is a rightward shift that means. Caine: partial agonist have a limited maximum affect regardless of dose if plateaus lower than 100% Ps 333: chantix help to quit smoking nicotine acetylcholine receptor antagonist, partial opioid agonist buprenorphine helps with heroin addiction less craving for heroin. Blood brain barrier cocaine goes into brain, carbidopa 9parkinsons) does not corss, gets stopped chemical properties to get into brain: Get stopped: larger size, polar/nonpolar affects lipo phovidity cant crosss if lipophobic therapeutic window. Half-life the time it takes for your body to eliminate half of the drug dose.
