BIO* - Biology BIO* M121 Lecture Notes - Lecture 18: Leptin Receptor, Adipose Tissue, Leptin
9 Jun 2020
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Document Summary
In homeostatic systems, messages often travel from integrators to effectors in the form of hormones. Triglycerides are energy storage molecules abundant in adipocytes. In mice, mutations in the obese (ob) and diabetic (db) genes can cause obesity. These mice eat more and move less than their wild-type siblings. The ob gene codes for leptin, a polypeptide hormone. It is secreted into the blood by adipocytes. Leptin interacts with its receptor, located in various tissues and also parts of the brain that control feeding behavior. The db gene codes for the leptin receptor. Blood leptin levels vary with total adipose tissue mass. When mass falls below the set point, blood leptin decreases (appetite increases) Leptin levels rise with sufficient food intake (diminished appetite, Blood oxygen levels stabilization of adipose tissue mass) When blood oxygen level falls (hypoxia) or red blood cell counts are low (anemia), the kidneys release epo. Epo stimulates production of red blood cells (erythrocytes)
