BMS 300 Lecture Notes - Lecture 19: Lipid Bilayer, Phase Velocity, Axon Terminal

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1 Oct 2017
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Action potential propagation: in nonmyelinated axons, 1m/sec, in myelinated axons, 100m/sec, importance of v-gated channel distribution. The phospholipid bilayer and charge separation: opposite charge separated by a phospholipid bilayer, concept of capacitance, role of myelin in affecting charge separation, rapid conduction of charge effects in salt solution of axoplasm. Generator potential to action potential in a sensory neuron: stretch-activated channels, graded potential, amplitude proportional to the number of channels opened, opening v-gated channels at the trigger zone, summation of graded potentials to reach threshold, action potential propagation. V-gated na+ channels are distributed all along the axon. *at each of the intervals along the axon, we see an variant action potential. *if we don"t resurrect action potential at sites along the axon, it dies out quickly (like in yesterday"s lecture) *v-gated ca+ channels are in the axon terminal. Ligand-gated channels are in the input region of axon.

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