BIOL 031 Lecture Notes - Lecture 7: Hydrolysis, Motor Neuron, Myosin Head
Document Summary
The crossbridge cycle: how muscles generate force: myosin (ex. Calcium is response for the triggering of the binding at the myosin head. Power stroke: myosin head moves propelling thin filament toward center of muscle (movement of oar propelling boat) Thick and thin filaments detach (oar breaks contact with water) Myosin head returns to initial position (oar moved to new position, cycle starts again) Myosin head undergoes conformational changes which contracts back and forth to the actin. High energy form = wants to be in close contact with actin. Low energy form = needs hydrolysis (atp, energy: atp has to unbind myosin head from thin filament, aka take it out of the water. During a power stroke, myosin head goes toward center of the muscle and the (thin filaments) myosin head and thick filaments (actin) detach: requires energy, cycle begins again.