HSCI 301 Lecture Notes - Lecture 14: Substance P, Morphine, Mast Cell
1 Dec 2016
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Chapter 14: opiods: name the 3 opiod receptors (endogenous receptors in the body) Moa: decrease presynaptic neuron ca2+ influx (inhibits docking/release of excitatory neurotransmitters that are involved in feeling pain) inhibits ca2+ from coming into presynaptic cell. Increase postsynaptic neuron k+ efflux/pushes it out (hyperpolarizes - inhibits firing of post-synaptic neuron) less likely to fire less glutamate & substance p: what are the indications and list the. Euphoria mu 2 (strong feeling of wellbeing) Respiratory depression mu 2 (reduced sensitivity of respiratory center neurons to co2 most common cause of death in opiod overdose) Emesis mu (chemoreceptor trigger zone = vomit) Gi tract decrease motility mu 2 (causes constipation) Cardiovascular mu (hypotension/low bp & bradycardia/slow hr) Histamine release from mast cells mu (itching, sweating, and vasodilation) Physical dependence mu 1 the peak effect and duration compare to morphine, and why isn"t is recommended. Moa: acts as agonist on kappa receptors (primary agonist) but not as much effect on mu receptors.
