BIOL 101 Lecture Notes - Lecture 29: Cardiovascular Disease, Microrna, Triglyceride
29 Jul 2020
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This type of epigenetic regulation is more complex and less analyzed in human epidemiological studies. The main post-translational modifications that can take place in histones include, among others: acetylation, phosphorylation, methylation or ubiquitinization, and influence the state of compaction of chromatin 20. Histones have a globular carboxyl terminal domain and an amino terminal tail, which is where the modifications take place. But these modifications do not occur anywhere, but rather respond to highly structured regulatory codes. Thus, for example, methylations occur at the lysine (abbreviated as k) and arginine (r) residues; acetylations, in lysine residues; ubiquitination, in lysines; phosphorylation, in serines (s) and threonines (t), The type of histone in which the modification occurs also influences the result . 7this selective histone modification process is graphically presented. Furthermore, it has been reported that histone enzymes are more under-expressed than over-expressed when metabolic diseases occur 43 .
