PSY 433 Lecture Notes - Lecture 43: Qt Interval, Isozyme, Fluoxetine
29 Jul 2020
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Atomoxetine molecule: pharmacokinetics. (simpson et al. , 2003) Atomoxetine is easily absorbed after oral administration and is little affected by food. It usually reaches the maximum plasma doses in 1-2 hours. Its bioavailability is 63% in rapid metabolisers (usecytochrome 2d6 sustr ato) and 94% in slow metabolizers. Clereance is approximately 5 hours in rapid metabolizates and about 21 hours in slow metabolizates, being its protein binding of 98%. It undergoes a cyp2d6 metabolic biotransformation process and that is why its association with inhibitors of this isoenzyme such as paroxetine, fluoxetine and quinidona increases serum levels of atomoxetine forcing a dose adjustment. This is important when we dec. idamos mantener la atomoxetina en el tratamiento de una comorbilidad depresiva. The main metabolite formed is 4-hydroxytoxetin o-glucuronic and is equipotent with atomoxetine. It is eliminated by 80% by urine and the rest by faeces: farmacodinamia. (simpson y passes, 2003) Atomoxetine is a selective inhibitor of the long-acting presynamine transporter of noradrenaline.
