PCB 4674 Lecture Notes - Lecture 7: Neutral Mutation, Mutation Rate, Absolute Time And Space
22 Sep 2016
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Document Summary
Non-coding regions: created as a result of a duplication event. Because they are extra, mutations within them is almost always neutral: provides a good check of the neutral theory. Research shows that pseudogenes do in fact accumulate mutations at a rate = to v: recall v = neutral mutation rate. In humans, 2. 5 x 10-8 per nuc site per generation: this is the standard mutation rate, this rate is also the same for non-coding regions. Mutations in coding regions: two basic types of coding region mutation synonymous (aka silent) Nonsynonymous (aka replacement: synonymous mutations do not change protein. Mutations that do not change amino acid sequence these should behave same as non-coding or pseudogenes: replacement mutations do change protein. Mutations that change one or more amino acids in a protein: back to flu virus data: Both types of regions accumulated substitutions in a linear (i. e. clocklike ) fashion. But the synonymous regions accumulated more of them.
