PCB 4674 Lecture Notes - Lecture 10: Allele, Chromosome, Haplotype
29 Oct 2016
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Evolution at two loci: so far we have only considered individual loci this makes hw analyses relatively simple. But not particularly realistic for many loci: most organisms comprised of 1000s of loci. Sufficiently close together such that crossover between them is rare: we begin with a relatively simple extension of previous examples. Consider two linked loci, rather than just one. Haplotype, short for haploid genotype: our main question is: if there is selection at the a locus. Will that prevent us from making predictions regarding evolution at the. B locus: consider 2 loci: a or a, b or b there are 4 possible chromosome genotypes. Ab, ab, ab, ab four different haplotypes. Key concepts and terms: allele frequencies are the same, chromosome frequencies are different, consider (f) of b on a and. In pop 1, ab = 12/15 = 0. 8 and ab = 8/10 = 0. 8. Consider that aabb is resistant to a lethal pathogen.
