BSC 1086C Lecture Notes - Lecture 6: Memory T Cell, Rheumatoid Arthritis, Adalimumab
Document Summary
Antibodies inactivate and tag antigens: form antigen-antibody complexes. Produced by hybridomas=cell hybrids: fusion of a tumore cell and a b cell. Proliferate indefinitely and have the ability to produce a single type of antibody. Used in research, clinical testing, and cancer treatment: trastuzumab: interferes with a her2/neu receptor of certain breast cancers, adalimumab: human monoclonal antibody in rheumatoid arthritis; bins to tnf, preventing it from activating tnf receptors. T cells provide defense against intracellular antigens: body cells infected by viruses or bacteria, cells that are abnormal or cancerous, cells of infused or transplanted foreign tissue, two types of surface receptors of t cells. Play a role in t cell interactions with other cells. Major types of t cells: cd4 cells become helper t cells when activated, cd8 cells become cytotoxic t cells that destroy cells harboring foreign antigens. Other types of t cells: regulatory t cells, memory t cells.
