BIOL 3450 Lecture Notes - Lecture 2: Acid Dissociation Constant, Metabolomics, Glutamine

• School: Georgia Tech
• Department: Biology
• Course: BIOL 3450
• Professor: All

Document Summary

Ex. anomeric form alpha vs beta linkages. Macromolecules: polysaccharides, proteins, amino acids building blocks of proteins pka ~ 10 pka ~ 8. 4, ex. If valine is substituted with glutamic acid (e), there will be deformation of tertiary structure and function change of quaternary structure: nucleic acids. Elements of biologic toolkit: gene (genomics) mrna (transcriptomics) protein (proteomics) structure / Function (metabolomics: human 2 sets of 23 dna molecules comprised of 3*109 nucleotide pairs and 20,000 protein coding genes, 109 molecules / cell. Four key concepts of chemistry of life: molecular complementarity, noncovalent interactions, hydrophobic interaction, van der waals, hydrogen bonds, chemical building blocks, chemical equilibrium, chemical bond energy. Trans double bond naturally occurring fatty acids should be in cis. Fatty acids have even number of carbons one chain has odd number of carbons. 0 , 0, -1, -1 net charges: higher cholesterol content, higher temp of mp more stable and rigid membrane becomes, ex.