RIU 330 Lecture Notes - Lecture 50: Cancer, Anaplasia, Rhabdomyoma
27 Sep 2020
School
Department
Course
Professor
Document Summary
Neoplasia- meaning new growth - uncontrolled growth of cells whose proliferation cannot be adequate controlled by normal regulatory mechanisms operating in normal tissues. The proliferation of normal cells is regulated internally by 1) the genetic program of each cell, 2) signals transmitted from one cell to another through direct contact 3) various soluble substances that have growth-promoting or growth-inhibiting effects. Once the cells stop proliferating, they assume specialized functions by activating a set of genes specific for each cell type. Differentiation: the process by which cells acquire specialized functions and tissue-or organ-specific features. In contrast: the proliferation of neoplastic cells as follows: Autonomous- independent of growth factors and stimuli that promote the growth of normal cells. Excessive- uncessing in response to normal regulators of cellular proliferation. Disorganized- not given to following the rules governing formation of normal tissues and organs. Proliferation of neoplastic cells leads to the formation of masses:
