A S L 3 Lecture Notes - Lecture 12: Thromboxane, Triiodothyronine, Neurotransmitter
Document Summary
Endocrinology is study of: hormones, glands that release them, target organs they act on. Some hormones are derived from aa precursors: catecholamines & thyroid hormones from tyrosine, dopamine, noradrenaline, adrenaline, triiodothyronine (t3, thyroxine (t4) Serotonin from tryptophan: 5-ht (actual name, rapidly broken down after their release. Peptide/protein hormones: hormones can be small peptides or full proteins, may contain carbohydrates (glycoproteins) Synthesised as precursors and stored prior to release: regulates activity and half life, activates receptors which signal to second messengers which include transcription factors. Steroid/lipid hormones: derived from cholesterol - . Hormone receptors: g protein-coupled receptors, adrenoreceptors, tyrosine kinase receptors. Calcium regulation: ca2+ movement across membranes is important in triggering many physiological mechanisms, neurotransmitter release at synapse, muscle contraction. Secretory mechanisms for hormones & enzymes: ca2+ are controlled by parathyroid hormone and vitamin d, active vitamin d promotes ca2+ absorption & promotes mineralisation of bone.
