BISC 310 Lecture Notes - Lecture 5: Pyrimidine, Sickle-Cell Disease, Primase
2 Nov 2016
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Watson and f. h. c. crick (nature: information can be encoded in many ways, in a dna molecule, information is encoded in the sequence of nucleotide bases. It all depends on where the mutation is: examples of dna damage, depurination- base lost from nucleotide, but the sugar- phosphate backbone remains unchanged, may result from interaction of water surrounding. 6-23: loss of the amino group (nh2) from the nucleotide base cytosine, this causes a change in the base from cytosine to uracil (c --> u, don"t get amino acids (nh2, phosphate - c - Cooh; r-group) and amino groups (nh2) mixed up: chemical attack, dna has multiple sites that are vulnerable to being attacked by multiple chemical agents, oxidation, hydrolytic attack, methylation, pyrimidine dimers (dimer = two units) (fig. Thymine dimer: a-t hydrogen bond is broken by absorption of uv radiation, two ts on the same parent strand of dna form a covalent bond, this prevents transcription from being able to.
