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Lecture 48

ANP 330 Lecture 48: ANP 330

Course Code
ANP 330

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ANP 330 Lecture 48
Peptic ulcer disease
sometimes referred to as a gastric, duodenal, or esophageal ulcer- it is an
excavation (hollow) that forms in the mucosal wall of the stomach- erosion of the
mucosal lining. Diagnosed with an EGD
Peptic ulcer disease
patient presents with dyspnea, heartburn, bloating, nausea occasionally vomiting,
fullness or hunger, dull gnawing pain or burning at the mid-epigastrium or back,
distention, bloody stool or emesis, wt. loss
Perforation or hemorrhage, pernicious anemia, dumping syndrome, pyloric
complications of peptic ulcers
Pernicious anemia
complication of peptic ulcer disease that occurs due to a deficiency of the intrinsic
factor normally secreted by the gastric mucosa- symptoms include: pallor, glossitis,
fatigue, and paresthesia. Treatment is lifelong monthly vitamin B12 injections
Dumping syndrome
complication of peptic ulcer disease- rapid gastric emptying. Symptoms include:
fullness, weakness, diaphoresis, palpitations, dizziness, and drowsiness, rapid
release of blood glucose followed by increase of insulin production causing
hypoglycemia. Treatment: lying down after meals, small sips of fluids, no liquids
with meals, eat high protein/fat and low fiber/carb meals, no mils and sugars, small
frequent meals
Proton-pump inhibitors
if used long term these medications can increase the risk of fractures, pneumonia,
acid rebound, and cdiff, alcohol and NSAIDS should be avoided and do not crush
Antibiotics, proton pump inhibitors, and bismuth salts
medications used to treat peptic ulcer disease
Amoxicillin, clarithromycin, metronidazole, tetracycline
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