BIOL 003 Lecture Notes - Lecture 8: B-Cell Receptor, Fc Receptor, Complement Receptor
25 May 2020
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Document Summary
B cells will deal with these; they have receptors that are membrane bound antibodies = b. Cell receptor; antibody can attach to antigen on bacteria; provides signal for the activation of the b cell. Once bacteria is bound by two antibodies and gives the first signal, it also triggers. B cell presents antigens in context of mhc 2; th2 cell is activated by two signals from the tcr and cd28/b7; produces th2 cytokines. Th2 cell now expresses cd40 ligand which will interact with the cd40 protein on the b cell to produce a second signal to activate b cell. Activate b cell now produces and secretes antibodies to attach to bacteria and eliminate it. B cells make antibodies, mature in bone marrow. B cell surface receptor is actually specific antibody molecule. All antibodies have similar structure, two identical heavy chains joined to two identical light chains amino terminus of heavy and light chain create the antigen binding.
