BIOL 230W Lecture 16: BIOL 230W - Lecture 16 - Introduction to Mitosis
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Biol 230w lecture 16 introduction to mitosis. Interphase: uncondensed dna (euchromatin, g0, g1, s, g2 phases, g1 and g2 checkpoints. Chromatids line up in center: anaphase, telophase, metaphase checkpoint. Mitosis functions to transfer replicated dna of parent cell to two identical daughter cells. Chromosomes are replicated into two sister chromatids: s phase. Each new cell inherits a complete nuclear genome from parent. Centromere: region where sister chromatids are connected: spatial. Kinetochore: protein complex associated with chromosome segregation. Centrosome: two centrioles and associated proteins: duplicate prior to mitosis, centrioles are tubular structures made of protein tubulin. Dynamic polymers of tubulin dimers that form a hollow tube structure. Dimer = alpha and beta subunits: + and ends. Grow (polymerize) from + end: dynamic, not associated with positive charge. Shrink (depolymerize) from end: not associated with negative charge. After prometaphase, microtubules grow and invade the nuclear space and attach to the kinetochore.
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