01:119:115 Lecture Notes - Lecture 8: Lethal Allele, Homologous Chromosome, Heterozygote Advantage
18 Oct 2016
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Genetics scientific study of inherited variation. Ca(cid:374)"t do e(cid:454)peri(cid:373)e(cid:374)tal (cid:373)ati(cid:374)g (cid:271)et(cid:449)ee(cid:374) i(cid:374)di(cid:448)iduals unethical & illegal. Instead analyze results of mating that have already occurred. Pedigree analysis study of family tree. Dna sequencing identify order of nucleotides: pedigree analysis. Shows inheritance patterns within the family over several generations. Predict inheritance of phenotypic traits that are controlled by genotype at single locus. Offspring in birth order from left to right. Shaded = having a specific trait being studied: recessively inherited disorders. Many genetic disorders are autosomal recessive. Recessive allele codes for malfunctioning protein or no protein at all. Heterozygote = carrier normal phenotype dominant allele makes enough protein. Homozygous recessive have disease 2 copies of gene usually born from carrier parents. Albinism autosomal recessive disorder lack of pigmentation in skin and hair. Cystic fibrosis most common lethal genetic disease in the us. Recessive allele defective or absent chloride transport channels in plasma membranes. Lead to buildup of cl- ions outside the cell.
