01:119:116 Lecture Notes - Lecture 18: Cochlea, Middle Ear, Inhibitory Postsynaptic Potential
5 Apr 2016
School
Department
Course
Professor
Document Summary
Describe from stimulus to the brain, stimulus, ap, synapse. Junction between synapse term and another neuron or effector. Vesicles fuse with terminal membrane and release neurotransmitter. Ligand- receptor protein, binds & responds to neurotransmitters a) Opens channel & allows specific ions to diffuse across postsynaptic membrane. If epsp is too small by axon hillock- no signal. If membrane reaches threshold (-55 mv)-> ap! ane. Glutamate- major excitatory neurotransmitter in brain (amino acid) Changes in synaptic connections underlie memory and learning. Most of reshaping occurs at synapses a) b) c) Synapses often work together- strengthens (use it or lose it) Links to hippocampus replaced by connections within cerebral cortex. Lasting increase in strength of synaptic transmission- days to weeks. At presynaptic neuron- high freq series of ap arriving at same time &-> glutamate (excitatory neurotransmitter) At postsynaptic membrane-> glutamate receptors nmda or ampa. Ca influx triggers insertion of stored ampa receptors into postsynaptic membrane.
