PHYS 799 Lecture Notes - Lecture 7: Pattern Recognition Receptor, Leukotriene B4, Inflammasome
23 Apr 2019
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Document Summary
Response to injury/infection vascular and cellular components, mediated by chemicals. Acute rapid onset, short duration, edema, neutrophils. Chronic slower onset, longer duration, fibrosis and angiogenesis, lymphocytes/macrophages. Cardinal signs of inflammation: redness, swelling, heat, pain, (loss of function) Vascular vasodilation (redness and warmth), increased vascular permeability. Cellular leukocytes exit circulation and accumulate at foci of injury. Causes infections, trauma, physical/chemical agents, necrosis, foreign bodies, immune reactions (hypersensitivity) Key pattern recognition receptors (prrs) that recognize foreign substances and necrotic cells: Toll-like receptors on cell surface and endosomes; stimulate cytokine secretion, expression of adhesion molecules. Inflammasome cytoplasmic, assembled by nod-like receptors; recognizes products of dead cells, crystals (uric acid, cholesterol), microbial products, free fatty acids; activates il-1beta (leukocyte recruitment) Fluid leaving blood vessels is exudate high protein content, w/cells (as opposed to transudate, which is just fluid) Leukocyte extravasation: margination, rolling (via selectins), adhesion (via integrins), migration across endothelium (diapedesis, via pecam-1), migration in interstitial tissue (chemotaxis)
