NSG 3336 Lecture Notes - Lecture 62: Costovertebral Angle Tenderness, Polycystic Kidney Disease, Chronic Kidney Disease
Document Summary
Childhood or infancy pkd is less common and is rapid and progressive, leading to serious lung and liver dysfunction and end stage renal disease (esrd) causing death > autosomal recessive. Adult pkd is fairly common characterized by cysts not limited to the kidneys but may also present in the liver, spleen, and pancreas > autosomal dominant. Lies dormant for many years and appears around age 30-40. Pathophysiology = cysts develop as a result of a repeat cell division process within the renal tubule known as cystogenic. Cysts become larger and compress surrounding tissue, destroying renal tissue. > reduces blood ow and subsequent nutrient supply to the renal tissues. Clinical manifestations > none in early stages, but then to appear as cysts become larger. First symptoms = htn > results of damage to surrounding renal structures caused by enlargement of cysts. Lowe bak or ank pain, headache, or pain in the abdominal are.
