BIOL 221 Lecture Notes - Lecture 4: Myogenic Mechanism, Angiogenesis, Perfusion
11 Feb 2020
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Document Summary
Delivery of blood to the tissues is referred to as tissue perfusion. It is based in part on mean arterial pressure. Tissue perfusion is important to: delivery oxygen & nutrients to all body tissues, removal of wastes from tissues, gas exchange in lung, absorption of nutrients from gut; and urine production in the kidney. Blood flow into tissues is largely under local (intrinsic) regulation that adjusts to meet the needs of the tissue served. Cell death or necrosis may result when perfusion is inadequate. In the long term, angiogenesis the formation of new blood vessels solves the problem of providing adequate blood perfusion. The more active a tissue is over time, the more angiogenesis is stimulated. Aerobic exercise has the added benefit (besides increasing lipid metabolism) of increasing angiogenesis in skeletal muscle and the heart. Angiogenesis in the latter helps protect against heart attack later in life.
