BIOL 221 Lecture Notes - Lecture 6: Natural Killer Cell, Mast Cell, Leukotriene

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Basophils and mast cells: basophils enter infected tissues, mast cells located mainly in areolar ct, both: release histamine and leukotrienes. Basophils are produced in the bone marrow and circulate in low numbers in the blood. They enter tissues that have become infected. Mast cells have a different origin and are mainly located in areolar connective tissues. Both release histamine and chemicals called leukotrienes, which promote inflammation. Natural killer (nk) cells: large, granular lymphocytes, immunological surveillance. Immunological escape: produce other chemicals that enhance inflammation. Natural killer (nk) cells account for up to 15% of circulating lymphocytes. They are responsible for immunological surveillance; that is, they respond to abnormal antigens on body cells caused by viral infection or cancer-causing mutations. When they encounter these abnormal pathogens, they release perforins that are inserted into the plasma membrane of the target cell. Immunological escape occurs when cancer cells avoid detection by not having specific antigens or by destroying nk cells.

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