BIOL 221 Lecture 6: TOPIC 6-5
1 Mar 2020
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Process of inflammation: vascular changes: vasodilation and increased capillary permeability: Exudate formation: clotting proteins, heparin, pain (dolor) and swelling (tumor) The process of inflammation begins with release of inflammatory chemicals. These cause the vascular changes vasodilation and increased capillary permeability. Vasodilation results in hyperemia (increased blood flow to area) and exudate formation (loss of fluid containing plasma proteins to tissue). Hyperemia brings in more blood, oxygen and nutrients to support increased cellular metabolism; the increased temperature may denature some pathogenic proteins as well as increased activity of leukocytes. Exudate formation includes leakage of clotting proteins into the tissue; these proteins wall off the pathogen to limit spread and forms a network for tissue repair. The additional fluid in the tissue results in pain and swelling. Process of inflammation (con"t: phagocyte mobilization and action. Mobilization of phagocytes is stimulated by chemicals (especially histamine, kinins, leukotrienes) that promote chemotaxis, which draws leukocytes to the injured area.
